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Research Output

Cancer transmissions and non-transmissions from solid organ transplantation in an Australian cohort of deceased and living organ donors

 We sought to identify cases of cancer transmission or non-transmission from transplantation in an Australian cohort of donors and recipients. We included NSW solid organ deceased donors 2000-2012 and living donors 2004-2012 in a retrospective cohort using linked data from the NSW Biovigilance Register (SAFEBOD).… Read More »Cancer transmissions and non-transmissions from solid organ transplantation in an Australian cohort of deceased and living organ donors

Characteristics and Donation Outcomes of Potential Organ Donors Perceived to be at Increased Risk for Blood Borne Virus Transmission

an Australian Cohort Study 2010-2018 With hepatitis C (HCV) curative therapy, more potential donors may now be suitable. We sought to describe potential deceased donors with increased BBV transmission risk. We conducted a cohort study of all potential organ donors referred in New South Wales,… Read More »Characteristics and Donation Outcomes of Potential Organ Donors Perceived to be at Increased Risk for Blood Borne Virus Transmission

New blood-borne virus infections among organ transplant recipients: An Australian data-linked cohort study examining donor transmissions and other HIV, hepatitis C and hepatitis B notifications (project: SAFEBOD)

We aimed to quantify post-transplant viral infections, specifically those transmitted by donors and those reactivating or arising new in recipients. Find full text here: New blood-borne virus infections among organ transplant recipients: An Australian data-linked cohort study examining donor transmissions and other HIV, hepatitis C… Read More »New blood-borne virus infections among organ transplant recipients: An Australian data-linked cohort study examining donor transmissions and other HIV, hepatitis C and hepatitis B notifications (project: SAFEBOD)

Safety and Biovigilance in Organ Donation (SAFEBOD): Protocol for a Population-Based Cohort Study

The Safety and Biovigilance in Organ Donation (SAFEBOD) study aims to improve estimates of infection and cancer transmission risk and explore how real-time data access could support decision-making. Find the full text here: Safety and Biovigilance in Organ Donation (SAFEBOD): Protocol for a Population-Based Cohort… Read More »Safety and Biovigilance in Organ Donation (SAFEBOD): Protocol for a Population-Based Cohort Study

Cardiovascular Mortality in Transplant Patients; A Population-Based Cohort Study 1988-2013 in Australia and New Zealand (project: CELESTIAL)

During 1988-2013, of 5286 deaths in 17,628 kidney transplant recipients, 934(17.8%) were cardiac. Kidney transplant recipients had greatly increased risk of cardiac mortality compared to the general population, but this has improved over time. Although male recipients have higher absolute risk, female recipients have a… Read More »Cardiovascular Mortality in Transplant Patients; A Population-Based Cohort Study 1988-2013 in Australia and New Zealand (project: CELESTIAL)

Cancer mortality in kidney transplant recipients: An Australian and New Zealand population‐based cohort study, 1980–2013 (project: CELESTIAL)

We looked at the cause of death for all kidney transplant recipients in Australia and New Zealand 1980-2013. There were 5,284 deaths in 17,628 kidney transplant recipients including 1,061 (20%) cancer deaths. Our study showed cancer mortality in kidney transplant recipients was overall 3 times… Read More »Cancer mortality in kidney transplant recipients: An Australian and New Zealand population‐based cohort study, 1980–2013 (project: CELESTIAL)

Weekend effect: analysing temporal trends in solid organ donation (project: ORCHARD)

Other research suggests patients treated over weekends experience poorer outcomes. One study performed in the USA suggested that fewer organ retrievals happen at weekends, and of those organs retrieved, more are discarded and not used than during the week. The CODE team thought it was… Read More »Weekend effect: analysing temporal trends in solid organ donation (project: ORCHARD)

Residual risk of infection with blood‐borne viruses in potential organ donors at increased risk of infection: systematic review and meta‐analysis

When potential donors are referred for consideration, if there is potential that they have an infection that could be transmitted to any organ transplant recipients, that donor is usually declined. Our work showed that they are often declined even when tests don’t show these infections.… Read More »Residual risk of infection with blood‐borne viruses in potential organ donors at increased risk of infection: systematic review and meta‐analysis

Epidemiology and Comorbidity Burden of Organ Donor Referrals in Australia: Cohort Study 2010–2015 (project: ORCHARD)

This study looked at all cases referred to the donation service and found that over time, although more people have been organ donors, a much larger proportion are declined for donation. Referral evaluation of potential donors is resource-intensive. We found the comorbidity burden among donor… Read More »Epidemiology and Comorbidity Burden of Organ Donor Referrals in Australia: Cohort Study 2010–2015 (project: ORCHARD)

Excess Stroke Deaths in Kidney Transplant Recipients: A Retrospective Population-based Cohort Study Using Data Linkage (project: CELESTIAL)

Among 17 628 kidney transplant recipients, we found 158 deaths from stroke. This was 19 times higher for women and 9 times higher for men than expected in the general population. Higher risk of stroke death was associated with older age at transplant, ever graft… Read More »Excess Stroke Deaths in Kidney Transplant Recipients: A Retrospective Population-based Cohort Study Using Data Linkage (project: CELESTIAL)