MODUS – Maximising Organ Donor offer Utility System-wide

MODUS is funded by an NHMRC partnership grant. The CODE team’s partners in the MODUS study are the NSW Ministry of Health, Kidney Health Australia, and the NSW Organ and Tissue Donation Service. 

MODUS will develop evidence to support policy and complex clinical decisions in the organ donor referral process in Australia. Using our SAFEBOD linked data as the cohort study platform, we will use advanced statistical methods to better understand retrospective donor referral risk profiles, and determine any potential donor gains that could be made through varying the acceptable biovigilance risk thresholds for accepting donors. Using dynamic compartmental economic modelling, we will investigate the impact of varying donor referral decisions on quality, safety and value of kidney transplant outcomes (transplant and recipient survival). Using results from these exercises, with a pre-post design, we will prospectively evaluate the impact of provision of donor risk profile and absolute biovigilance risk estimates to clinicians on donor referral decision-making.

 

MODUS – Maximising Organ Donor offer Utility System-wide

Research Publications

2023

Hedley, James A.; Kelly, Patrick J.; Wyld, Melanie; Shah, Karan; Morton, Rachael L.; Byrnes, Juliet; Rosales, Brenda M.; Mata, Nicole L. De La; Wyburn, Kate; Webster, Angela C.

Cost-effectiveness of Interventions to Increase Utilization of Kidneys From Deceased Donors With Primary Brain Malignancy in an Australian Setting Journal Article

In: vol. 9, no. 5, 2023, ISSN: 2373-8731.

Abstract | Links | BibTeX

Shah, Karan K.; Wyld, Melanie; Hedley, James A.; Waller, Karen M. J.; Mata, Nicole De La; Webster, Angela C.; Morton, Rachael L.

Cost-effectiveness of Kidney Transplantation From Donors at Increased Risk of Blood-borne Virus Infection Transmission Journal Article

In: vol. 107, no. 9, pp. 2028–2042, 2023, ISSN: 0041-1337.

Abstract | Links | BibTeX

2022

Thomson, Imogen K.; Hedley, James; Rosales, Brenda M.; Wyburn, Kate; O'Leary, Michael J.; Webster, Angela C.

Potential organ donors with primary brain tumours: missed opportunities for donation and transplantation identified in Australian cohort study 2010–2015 Journal Article

In: ANZ Journal of Surgery, vol. 92, no. 11, pp. 2996–3003, 2022, ISSN: 1445-2197.

Abstract | Links | BibTeX

Waller, Karen M. J.; Mata, Nicole L. De La; Rosales, Brenda M.; Hedley, James A.; Kelly, Patrick J.; Thomson, Imogen K.; O’Leary, Michael J.; Cavazzoni, Elena; Ramachandran, Vidiya; Rawlinson, William D.; Wyburn, Kate R.; Webster, Angela C.

Characteristics and Donation Outcomes of Potential Organ Donors Perceived to Be at Increased Risk for Blood-borne Virus Transmission: An Australian Cohort Study 2010–2018 Journal Article

In: vol. 106, no. 2, pp. 348–357, 2022, ISSN: 0041-1337.

Abstract | Links | BibTeX

2020

Waller, Karen M. J.; Mata, Nicole L. De La; Hedley, James A.; Rosales, Brenda M.; O'Leary, Michael J.; Cavazzoni, Elena; Ramachandran, Vidiya; Rawlinson, William D.; Kelly, Patrick J.; Wyburn, Kate R.; Webster, Angela C.

New blood‐borne virus infections among organ transplant recipients: An Australian data‐linked cohort study examining donor transmissions and other HIV, hepatitis C and hepatitis B notifications, 2000‐2015 Journal Article

In: Transplant Infectious Dis, vol. 22, no. 6, 2020, ISSN: 1399-3062.

Abstract | Links | BibTeX

2019

Waller, Karen MJ; Mata, Nicole L De La; Kelly, Patrick J; Ramachandran, Vidiya; Rawlinson, William D; Wyburn, Kate R; Webster, Angela C

Residual risk of infection with blood‐borne viruses in potential organ donors at increased risk of infection: systematic review and meta‐analysis Journal Article

In: Medical Journal of Australia, vol. 211, no. 9, pp. 414–420, 2019, ISSN: 1326-5377.

Links | BibTeX